Table 2

Antibiotic resistance genes in A. baumannii ABIsac_ColiR genome

Antibiotic classGeneSize (aa)aFunctionbOrganism with the best BLAST hit in GenBank% aa identityE value
Beta-lactamsampC432Class C beta-lactamase (transpeptidase superfamily)A. baumannii ACICU1000
350Predicted Zn-dependent hydrolase of the beta-lactamase foldA. baumannii ACICU1000
309Metallo-beta-lactamase domain proteinA. baumannii 60140591001e−177
blaOXA-23273Class D carbapenemase OXA-23A. baumannii TCDC-AB07151001e−159
414Beta-lactamase class AA. baumannii ACICU1000
blaOXA-82(blaOXA-51-like)274Class D carbapenemase OXA-82A. baumannii ABNIH31001e−159
288Metallo-beta-lactamase domain proteinA. baumannii ACICU100.001e−171
ampC384Beta-lactamase/d-alanine carboxypeptidase (transpeptidase superfamily)A. baumannii MDR-ZJ0699.000
810Predicted hydrolase of the metallo-beta-lactamase superfamily (class C beta-lactamase)A. baumannii TCDC-AB071599.000
227Putative metallo-beta-lactamaseA. baumannii AB056991e−168
AminoglycosidesadeT335RND-type efflux pump involved in aminoglycoside resistance/substrate-binding protein, aliphatic sulfonate familyA. baumannii SDF1000
adeT355RND-type efflux pump involved in aminoglycoside resistance/TRAP-type C-4-dicarboxylate transport system, periplasmic componentA. baumannii 1656-2990
334RND-type efflux pump involved in aminoglycoside resistance/transporterA. baumannii AYE990
aphA6259Aminoglycoside 3′-phosphotransferase/kanamycin resistance proteinA. baumannii AB05899.601e−143
aadB198Aminoglycoside-2″-adenylyltransferase/gentamicin resistance proteinSalmonella enterica serovar Typhimurium1001e−111
aadA2259Aminoglycoside adenylyltransferase/streptomycin adenylyltransferaseYersinia pestis biovar Orientalis IP27599.6141e−147
329Aminoglycoside phosphotransferaseA. baumannii ACICU1000
MacrolidesmacB664Macrolide-specific efflux protein MacB/ABC transporter permeaseA. baumannii ACICU1000
macA446Macrolide-specific efflux protein MacA/membrane fusion proteinA. baumannii ACICU1000
Sulfonamidesul1279Dihydropteroate synthaseE. coli FVEC14121000
Bicyclomycin514Bicyclomycin resistance proteinA. baumannii AYE1001e−139
Chloramphenicolcmr409Major facilitator superfamily multidrug/chloramphenicol efflux transporterA. baumannii AYE99.760
catB2210Chloramphenicol acetyltransferaseA. baumannii AYE1001e−122
ColistinpmrA mutated (E8D)224Transcriptional regulatory protein/polymyxin resistance proteinA. baumannii AYE99.551e−126
RifampinrpoB mutated (D525Y)1362DNA-directed RNA polymerase subunit betaA. baumannii AYE99.930
FluoroquinolonesgyrA mutated (S83L, G145D, S218G, L644P, T872A)905DNA gyrase, A subunit/type IIA topoisomeraseA. baumannii AYE990
parC mutated (S84L, E208G, S467G, A661V)740DNA topoisomerase IV subunit A/ParCA. baumannii AYE990
  • a aa, amino acids.

  • b RND, resistance-nodulation-cell division; TRAP transporter, tripartite ATP-independent periplasmic transporter.