Table 1

Mutational differences between DAP-susceptible and DNS isogenic strain pairs identified by whole-genome sequencing

Isolate pair and positionMutationaGeneFunctionReference
D592/D712b
    1440962T to CmprFPhosphatidylglycerol lysyltransferase4
    1608916A to GsrrBRespiratory response protein
    1960627G to ANA,d noncoding
    2448257C to ATranscriptional regulator
    2592882G to AEndo-1,4-beta-glucanase
J01/J03b
    42283C to TMobile element proteinThis study
    530079T deletionNA, indel, noncoding
    605255T to CrpoBDNA-directed RNA polymerase beta subunit
    832922T to CsecAProtein export cytoplasm protein SecA ATPase RNA helicase
    1440974C to TmprFPhosphatidylglycerol lysyltransferase
    27242196-bp deletionNA, indel in frame, hypothetical protein
O325/O510b
    20183A to GPhosphoesterase, DHH family proteinThis study
    901046A to GNA, noncoding
    946004G to APhage tail length tape measure protein
    1442416T to CmprFPhosphatidylglycerol lysyltransferase
    2219610T to CclsCardiolipin synthetase
JKD6000/JKD6001c
    24673G to AwalRResponse regulator10
    1217720G to ANA, noncoding
    2006385T to APutative phage protein
    2142758G to AdUTPase
    2142774T to GdUTPase
    2150689T to CAcetyltransferase
    2151557C to TNA, noncoding
JKD6004/JKD6005,c 25010A to GwalRResponse regulator10
  • a Parent-to-child strain.

  • b Reference genome S. aureus Mu50.

  • c Reference genome S. aureus JKD6008.

  • d NA, not applicable.