Table 1

Comparison of GSK5852 and HCV-796 in stable replicon and HCVcc assays

Assay systemGSK5852HCV-796
EC50 (nM)95% confidence interval (nM)nEC50 (nM)95% confidence interval (nM)n
Genotype 1a replicon (H77)3.02.8–3.38226.124.2–28.3139
Genotype 1b replicon (Con1)1.61.5–1.812516.916.0–17.7581
Genotype 1b replicon (C316N)1.91.6–2.226257242–274241
Genotype 2a replicon (JFH1)7.66.4–8.91692.680.7–10610
HCVcc virus (Jc1p7Fluc2a)4734–61a29593–98a2
  • a Range for values with n of <4.