Table 3

Activity of GSK5852 and HCV-796 against genotype 1a and 1b NS5B variants

Genotype and amino acid changeMean replication capacity ± SD (n)GSK5852 EC50 (95% confidence interval) (nM)nHCV-796 EC50 (95% confidence interval) (nM)n
Genotype 1a
    None100%0.73 (0.65–0.82)1311.9 (10.0–14.0)126
    C316FNDb16.4 (14.6–18.6)88,035 (7,080–9,120)a2
    C316Y7% ± 3% (3)3.25 (2.61–4.04)81,900 (1,300–2,800)38
    S365L2% ± 1% (3)226 (193–266)4400 (2.4–66,000)4
    S368F1% ± 1% (3)670 (557–806)89,000 (7,400–11,000)a2
    S368Y3% ± 3% (3)278 (260–299)4310 (23–4,100)6
    L392F180% ± 10% (3)1.83 (1.47–2.27)410.8 (9.0–13.0)4
Genotype 1b
    None100%0.83 (0.76–0.90)477.1 (6.6–7.6)69
    C316F7% ± 2% (3)3.78 (1.64–8.73)42,460 (2,000–3,030)8
    C316Y7% ± 8% (3)1.4 (0.81–2.40)8400 (320–510)16
    S365A72% ± 32% (3)0.31 (0.25–0.38)a2440 (340–560)10
    S365F14% ± 10% (3)28,300 (12,000–66,700)4ND0
    S365L6% ± 2% (3)110 (97.1–126)8>5,0001
    S365T9% ± 4% (3)4.2 (2.91–6.19)81,100 (420–2,900)11
    C445F171% ± 123% (3)1.85 (1.07–3.19)443 (34–54)10
    C316Y/C445FND22.4 (19.4–25.8)41,600 (590–4,200)6
  • a Range is for values with n of <4.

  • b ND, not determined.