Table 1

Susceptibilities of Gram-negative aerobic bacteria to eravacycline and comparatorsa

OrganismMIC50/90 (μg/ml), MIC range (μg/ml), and no. of isolates
ERVTETTGCCARBAG3rd GCFQCSTPTZ
Acinetobacter baumannii0.25/18/>320.5/42/328/>32>16/>32>2/>20.5/2>64/>128
0.016–8≤0.25–>32≤0.016–80.13–>32≤0.25–>320.13–>640.016–>320.13–>4≤0.5–>128
188159188188188128188155128
Acinetobacter baumannii CARB-I/R,b FQ-R,d AG-R0.5/2>8/>322/8>8/>32>8/>32>32/>32>4/160.5/1>64/>128
≤0.016–42–>320.13–8>8–>32>8–>32>16–>32>2–>320.13–>464–>128
524352525237524344
Acinetobacter baumannii TET-R0.5/2>8/>322/4>8/>32>8/>32>32/>32>4/320.5/1>64/>128
0.06–2>8–>320.25–8≤0.25–>32≤0.25–>324–>64≤0.25–>320.13–>44–>128
696969696939696856
Acinetobacter lwoffii0.13/0.251/20.13/0.5≤1/4≤0.25/11/16≤0.25/≤0.250.25/>2≤0.5/8
0.03–0.25≤0.25–>80.06–0.5≤0.25–>8≤0.25–>8≤0.5–>64≤0.25–2≤0.13–4≤0.5–16
343434343434343434
Burkholderia cenocepacia8/32>32/>328/3232/>32>32/>3216/324/8>32/>3216/>128
0.13–3216–>320.25–>321–>32>32–>322–>320.5–>32>32–>320.5–>128
101010101010101010
Citrobacter freundii0.25/11/>80.5/20.5/20.5/>81/32<0.25/>20.5/14/>128
0.06–20.5–>80.13–80.004–>32≤0.25–>320.06–>640.008–>40.25–>20.25–>128
1156511510311511511564115
Citrobacter freundii 3rd-GC-I/Rc0.5/12/81/21/160.5/>32>16/>641/>40.25/1>64/>128
0.13–21–>80.25–80.25–>32≤0.25–>324–>640.016–>40.25–>22–>128
421642394242421642
Enterobacter cloacae0.5/22/>80.5/20.5/20.5/82/>64≤0.25/>40.5/>44/>64
0.03–40.5–>320.06–80.03–>32≤0.25–>320.03–>640.008–>32≤0.13–>320.5–>128
270218270270270246270178220
Enterobacter cloacae 3rd-GC-I/R0.5/24/>81/40.5/40.5/16>32/>640.25/>40.25/>2>64/>128
0.03–41–>320.06–80.03–>32≤0.25–>322–>640.008–>32≤0.13–>322–>128
1229312212212212212281107
Enterobacter cloacae CARB-I/R0.5/24/>320.5/42/161/>32>32/>64≤0.25/>40.25/>4>64/>128
0.25–42–>320.13–4≤0.016–>32≤0.25–>320.13–>640.03–>32≤0.13–>321–>128
343134343426342121
Enterobacter cloacae FQ-R2/48/>322/40.5/81/>32>32/>64>4/320.25/1>64/>128
0.25–42–>320.25–8≤0.016–>32≤0.25–>320.5–>64>2–>32≤0.13–>42–>128
362936363635362127
Enterobacter cloacae AG-R0.5/28/>321/40.5/1616/>32>32/>64>2/>40.25/1>64/>128
0.25–41–>320.25–80.13–>32>8–>320.25–>64≤0.016–>32≤0.13–12–>128
262026262626261522
Enterobacter cloacae TET-R2/4>8/>321/40.25/21/>3232/>644/160.25/>416/>64
0.25–4>8–>320.25–80.03–>32≤0.25–>320.13–>640.03–>32≤0.13–>322–>128
252525252525252116
Enterobacter aerogenes0.25/12/80.5/2≤1/1≤0.25/0.5≤0.5/>32≤0.25/≤0.250.25/0.54/>64
0.13–20.5–>80.25–4≤0.25–8≤0.25–8≤0.5–>64≤0.25–>4≤0.13–>4≤0.5–>64
777777777777777777
Enterobacter aerogenes 3rd-GC-I/R0.25/12/80.5/20.5/1≤0.25/132/>32≤0.25/>40.25/164/>64
0.13–21–>80.25–4≤0.25–8≤0.25–24–>64≤0.25–>4≤0.13–18–>64
272727272727272727
Escherichia coli0.25/0.54/>320.25/0.50.25/0.51/>8≤0.5/>32≤0.25/>40.5/0.52/>64
≤0.016–40.25–>640.06–>8≤0.002–>32≤0.25–>32≤0.016–>64≤0.25–>32≤0.13–4≤0.5–>128
445390445445445445445216359
Escherichia coli 3rd-GC-I/R0.25/0.5>8/>320.25/10.06/0.52/>32>32/>64>4/320.25/0.58/128
≤0.016–10.5–>320.03–>8≤1–>32≤0.25–>322–>64≤0.25–>32≤0.13–4≤0.5–>128
1271131271271271271276993
Escherichia coli FQ-R0.25/0.5>8/>320.25/0.50.13/≤0.54/>32>16/>64>4/320.25/0.58/>64
≤0.016–40.25–>320.06–>8≤1–>320.25–>320.06–>64>2–>32≤0.13–41–>128
14311814314314314314372142
Escherichia coli AG-R0.25/0.5>8/>320.25/0.50.063/≤0.5>8/>3232/>64>4/320.25/0.58/>64
≤0.016–10.25–>320.063–>8≤1–>32>8–>320.06–>64≤0.25–>32≤0.13–0.5≤0.5–>128
796979797979794478
Escherichia coli AG-R, FQ-R, 3rd-GC-I/R0.25/0.5>8/>320.25/0.50.063/0.5>32/>32>32/>64>4/320.25/0.58/>128
≤0.016–10.5–>320.063–>8≤1–>32>8–>324–>64>2–>32≤0.12–0.51–>128
403540404040402140
Escherichia coli TET-R0.25/0.516/>320.25/0.50.063/≤0.52/>84/>321/320.25/0.54/>64
≤0.016–2>8–>640.06–4≤1–>32≤0.25–>320.06–>64≤0.25–>32≤0.13–4≤0.5–>128
15715715715715715715794148
Haemophilus influenzae0.13/0.250.5/10.13/0.251/2ND<0.03/0.130.016/0.03NDND
≤0.016–0.5≤0.06–16≤0.016–10.06–8ND≤0.016–0.50.004–0.13NDND
114114114101ND114114NDND
Klebsiella pneumoniae0.5/24/>320.5/20.25/>80.5/>88/>320.5/>320.5/18/>128
0.03–16≤0.25–>640.13–16≤0.002–>32≤0.25–>32≤0.016–>64≤0.25–>64≤0.13–>16≤0.5–>128
394339394394223394394209394
Klebsiella pneumoniae 3rd-GC-I/R0.5/28/>321/41/164/16>32/64>4/>320.5/4>64/>128
0.03–161–>640.13–16≤1–>320.25–>324–>64≤0.25–>64≤0.13–>160.5–>128
21018721021082210210110209
Klebsiella pneumoniae CARB-I/R0.5/28/>321/2>8/>324/>8>32/>32>4/>320.5/>4>64/>128
0.13–161–>320.25–162–>320.25–>321–>640.06–>640.13–>164–>128
908190905090905790
Klebsiella pneumoniae FQ-R0.5/28/>321/21/324/32>32/>32>4/>320.5/>4>64/>128
0.13–161–>320.13–16≤1–>32≤0.25–>320.25–>64>2–>640.13–>164–>128
1561341561568215615678156
Klebsiella pneumoniae AG-R0.5/28/>321/40.5/32>8/>32>32/>64>4/>320.5/1>64/>128
0.06–161–>320.13–16≤1–>32>8–>320.25–>64≤0.25–>64≤0.13–>162–>128
1191061191195911911961118
Klebsiella pneumoniae AG-R, FQ-R, 3rd-GC-I/R0.5/28/>321/41/32>8/>32>32/>328/>320.5/1>64/>128
0.13–162–>320.13–16≤1–>32>8–>328–>64>2–>640.13- >164–>128
746674743574743674
Klebsiella pneumoniae AG-R, FQ-R, CARB-I/R0.5/28/>321/2>8/>32>8/>32>32/>32>4/>320.5/>4>128/>128
0.13–164–>320.25–162–>32>8–>32>16–>64>2–>640.13–>16>64–>128
373337372137372137
Klebsiella oxytoca0.5/11/>320.5/2≤1/≤10.5/>32≤0.5/>32≤0.25/4≤0.13/0.132/16
0.03–20.5–>320.06–40.004–1≤0.13–>32≤0.016–>320.03–>320.03–>2≤0.5–>64
484848484848484148
Klebsiella oxytoca 3rd-GC-I/R0.5/1>32/>320.25/0.50.06/0.25>32/>32>32/>320.5/>320.13/0.138/>32
0.03–10.5–>320.06–10.03–10.5–>324–>320.03–>320.03–0.130.5–>32
111111111111111111
Legionella pneumophila1/24/8NDNDNDNDNDNDND
0.016–20.5–8NDNDNDNDNDNDND
7070NDNDNDNDNDNDND
Moraxella catarrhalis0.03/0.06≤0.25/0.50.06/0.13≤0.25/≤0.25≤0.25/≤0.25≤0.5/≤0.5≤0.25/≤0.251/1≤0.5/≤0.5
≤0.016–0.06≤0.06–>32≤0.016–0.13≤0.25–≤0.25≤0.06–0.25≤0.5–2≤0.25–≤0.250.5–2≤0.5–2
929292787878922828
Morganella morganii1/22/>82/4≤1/21/>8≤0.5/8≤0.25/4>2/>4≤0.5/2
0.5–40.5–>80.25–80.008–4≤0.25–>8≤0.016–>160.03–>4>2–>4≤0.5–>64
434343434343433943
Proteus mirabilis1/2>8/324/82/41/>8≤0.5/1≤0.25/>4>2/>4≤0.5/2
0.25–162–>640.5–160.008–>32≤0.25–>64≤0.016–>640.016–>64>2–>4≤0.016–64
16611116616616616616695157
Proteus mirabilis 3rd-GC-I/R1/4>8/644/84/88/168/>32>2/8ND2/4
0.5–8>8–641–160.25–320.5–>644–>64≤0.25–16>2–>4≤0.5–64
21152121212121919
Proteus mirabilis CARB-R1/4>8/324/82/81/>8≤0.5/2≤0.25/>4>2/>4≤0.5/2
0.25–162–>641–160.06–>32≤0.25–>64≤0.016–>640.016–>64>2–>4≤0.06–>64
1368113613613613613667127
Proteus mirabilis FQ-R2/4>8/644/84/82/16≤0.5/16>4/16>2/>41/2
0.5–16>8–>641–160.25–32≤0.25–>64≤0.016–>64>2–>64>2–>4≤0.13–64
432643434343431938
Proteus mirabilis AG-R2/4>8/>324/82/8>8/>64≤0.5/32>2/>4>2/>40.5/4
0.5–8>8–642–80.25–32>8–>64≤0.016–>640.016–32>2–>4≤0.13–8
241624242424241223
Proteus mirabilis TET-R1/2>8/324/82/81/>8≤0.5/1≤0.25/>4>2/>4≤0.5/2
0.25–16>8–>640.5–160.008–>32≤0.25–>64≤0.015–>640.03–>64>2–>4≤0.5–>64
10910910910910910910993100
Proteus vulgaris0.5/18/>82/4≤1/21/4≤0.5/32≤0.25/0.5>2/>2≤0.5/1
0.25–21–>80.5–8≤0.5–4≤0.25–>8≤0.03–>64≤0.25–4>2–>4≤0.5–4
555555555555555555
Providencia stuartii1/2>8/>82/42/44/32<0.5/16>2/>4>2/>24/64
0.13–8<0.25–>80.06–160.25–16≤0.25–>32≤0.016–>640.016–>4>2–>4≤0.13–>128
1015110110110110110151101
Pseudomonas aeruginosa8/32>8/6416/322/>82/>8>16/>321/>41/28/>128
1–>328–641–>320.13–>320.13–>321–>640.06–>320.25–4>64–>128
1459314514514514514585145
Salmonella spp.0.25/0.251/>80.25/0.5≤1/≤10.5/1≤0.5/≤0.5≤0.25/≤0.25≤0.13/0.52/4
0.13–0.50.5–>80.13–1≤1–8≤0.25–>8≤0.5–≤0.5≤0.25–>4≤0.13–21–64
303030303030303030
Serratia marcescens1/1>8/>81/20.5/10.5/1≤0.5/1≤0.25/1>2/>42/4
0.25–82–>80.5–4≤0.25–2≤0.25–8≤0.5–>64≤0.25–>40.25–>4≤0.5–>64
112112112112112112112112112
Shigella spp.0.13/0.5>8/>80.25/0.5≤1/≤11/1≤0.5/≤0.5≤0.25/0.5≤0.13/≤0.132/2
0.06–1≤0.25–>80.13–1≤1–≤1≤0.25–>8≤0.5–2≤0.25–1≤0.13–≤0.13≤0.5–4
303030303030303030
Stenotrophomonas maltophilia0.5/2>8/320.5/4>8/>32>8/>32>32/>321/>4>2/>32>64/>128
≤0.016–80.5–>320.03–82–>32≤0.25–>321–>640.13–32≤0.13–>328–>128
105105105105105105105104105
  • a CARB, carbapenem (imipenem, meropenem, or ertapenem); AG, aminoglycoside (gentamicin or tobramycin); 3rd-GC, third-generation cephalosporin (ceftazidime, cefotaxime, or ceftriaxone); FQ, fluoroquinolone (levofloxacin or ciprofloxacin); ERV, eravacycline; TET, tetracycline; TGC, tigecycline; CST, colistin; PTZ, piperacillin-tazobactam; ND, not determined.

  • b For Enterobacteriaceae, carbapenem-I/R isolates were defined as having an imipenem/meropenem MIC of ≥2 μg/ml or an ertapenem MIC of ≥1 μg/ml, and for Acinetobacter, carbapenem-I/R isolates were defined as having an imipenem/meropenem MIC of ≥16 μg/ml.

  • c Third-generation cephalosporin-I/R isolates were defined as having a ceftazidime MIC of ≥8 μg/ml and a cefotaxime/ceftriaxone MIC of ≥2 μg/ml.

  • d Fluoroquinolone-resistant (FQ-R) isolates were defined as having a levofloxacin MIC of ≥8 μg/ml or a ciprofloxacin MIC of ≥4 μg/ml.