Table 3

Susceptibilities of anaerobic bacteria to eravacycline and comparatorsa

OrganismMIC50/90 (μg/ml), MIC range (μg/ml), and no. of isolates
ERVTGCCARBMTZVAN
Actinomyces spp.NDNDNDNDND
0.25–0.250.25–0.5ND4–>16ND
55ND5ND
Anaerococcus spp.0.13/0.130.13/0.25ND2/2ND
0.03–0.250.06–0.25ND0.5–4ND
1010ND10ND
Bacteroides fragilis0.5/10.5/40.25/11/1>16/>16
0.06–20.13–80.13–40.25–>1616–>16
3636163111
B. fragilis cefinase positive0.5/11/4ND1/1ND
0.13–20.25–8ND0.25–1ND
2020ND20ND
Bacteroides ovatus1/40.5/160.25/0.251/2>16/>16
0.016–80.06–320.03–10.13–>168–>16
1111111010
Bacteroides thetaiotaomicron1/48/160.5/21/2>16/>16
0.13–40.25–160.13–40.5–>1616–>16
1111111010
Bacteroides vulgatus0.25/0.250.5/0.50.25/10.5/1>16/>16
0.13–10.13–40.25–10.5–116–>16
1212121010
Bifidobacterium spp.NDNDNDNDND
0.13–0.50.25–0.5ND2–>16ND
77ND6ND
Clostridium difficile0.06/0.130.13/0.134/81/11/2
0.03–0.250.06–0.50.25–80.5–20.5–4
1111111111
Clostridium perfringens1/21/40.13/0.54/161/>16
0.06–40.13–80.06–12–>160.5–>16
1111111010
Eggerthella lenta0.25/0.250.5/0.5ND0.5/0.5ND
0.25–0.250.25–0.5ND0.25–0.5ND
1212ND12ND
Finegoldia magna0.25/0.50.25/0.25ND0.5/1ND
0.13–0.50.13–0.25ND≤0.13–1ND
1010ND10ND
Fusobacterium spp.0.13/0.250.13/0.5ND≤0.13/0.25ND
0.03–0.250.06–0.5ND≤0.13–0.25ND
2121ND21ND
Lactobacillus spp.0.25/0.50.5/0.5ND>16/>16ND
0.25–10.25–1ND>16–>16ND
77ND7ND
Parabacteroides distasonis0.5/11/2ND1/1ND
0.25–10.25–4ND0.5–1ND
1010ND10ND
Peptoniphilus asaccharolyticus0.06/0.130.13/0.25ND1/2ND
0.03–0.130.06–0.25ND0.5–2ND
1010ND10ND
Peptostreptococcus anaerobius0.06/0.250.06/0.250.06/11/20.5/2
0.016–0.250.016–0.50.03–10.25–20.5–>16
1010101010
Peptostreptococcus micros0.016/0.250.03/0.250.016/0.030.25/>161/1
0.016–0.50.016–1≤0.008–0.03≤0.008–>160.5–2
1010101010
Porphyromonas asaccharolytica0.03/0.060.06/0.060.016/0.031/20.25/0.5
0.016–0.130.03–0.13≤0.008–0.060.5–40.13–1
1010101010
Prevotella bivia1/11/2ND1/4ND
0.13–10.03–2ND0.5–4ND
1313ND13ND
Prevotella buccae0.06/0.130.13/0.13ND0.5/1ND
0.03–0.130.06–0.25ND0.25–1ND
1010ND10ND
Prevotella disiens0.13/0.250.25/0.5ND1/1ND
0.06–0.250.13–0.5ND0.5–2ND
1212ND12ND
Prevotella intermedia0.06/0.130.25/0.25ND0.5/0.5ND
0.03–0.130.13–0.25ND0.25–1ND
1010ND10ND
Prevotella melaninogenica0.13/10.5/1ND0.25/1ND
0.06–10.06–4ND≤0.008–>161–>16
1313ND138
Prevotella spp.NDNDNDNDND
0.03–10.06–0.5ND0.25–>16ND
77ND7ND
Propionibacterium acnesNDNDNDNDND
0.13–0.130.13–0.13ND>16–>16ND
55ND5ND
  • a ERV, eravacycline; TGC, tigecycline; MTZ, metronidazole; VAN, vancomycin; CARB, ertapenem or imipenem; ND, not determined.