IC50s of recombinant neuraminidases tested in the fluorescent NI assay
NA substitution | Mean IC50 ± SDa [nM (foldb)] | |||
---|---|---|---|---|
Zanamivir | Oseltamivir | Peramivir | Laninamivir | |
E119V | 0.54 ± 0.13 (3) | 44.93 ± 3.76 (281) | 0.12 ± 0.02 (1) | 0.43 ± 0.08 (4) |
T148I | 1.33 ± 0.16 (6) | 0.04 ± 0.00 (1) | 0.06 ± 0.00 (1) | 0.34 ± 0.02 (3) |
E119V, T148I | 220.48 ± 14.00 (1,050) | 984.62 ± 76.60 (6,154) | 9.54 ± 1.67 (119) | 79.47 ± 10.30 (722) |
None | 0.21 ± 0.03 | 0.16 ± 0.07 | 0.08 ± 0.01 | 0.11 ± 0.04 |