Table 2

Motavizumab and mota-YTE mean pharmacokinetic parameter values

Dose and treatmentMean value for the parametera
Cmax (μg/ml)Clearance (ml/day)Half-life (days)Vol of distribution (liters)AUClast (μg · day/ml)AUCinf (μg · day/ml)
0.3 mg/kg
    Mota-YTE8.8 (16.2)58.5 (7.8)69.5 (2.4)5.8 (2.7)300.4 (3.8)342.8 (7.8)
    Motavizumab8.9 (24.1)203.2 (12.4)18.9 (28.3)5.3 (27.3)90.4 (14.6)99.5 (13.1)
3 mg/kg
    Mota-YTE82.8 (31.8)44.2 (19.6)100.4 (10.5)6.3 (17.3)4,193.3* (6.4)5,224.0* (4.2)
    Motavizumab59.3 (39.1)322.8 (46.7)22.3 (33.5)8.5 (39.7)784.6 (58.9)850.5 (56.8)
15 mg/kg
    Mota-YTE324.1 (15.0)67.5 (18.7)84.3 (18.6)8.3 (11.5)15,328.7 (11.4)18,022.3 (13.6)
    Motavizumab232.9 (4.3)325.6 (34.2)20.4 (52.2)9.5 (12.7)2,903.8 (19.0)3,262.1 (26.8)
30 mg/kg
    Mota-YTE938.1 (3.6)43.3 (3.8)73.2 (4.0)4.6 (1.1)44,159.4 (14.9)49,276.6 (13.7)
    Motavizumab898.2 (13.9)164.9 (33.7)34.4 (25.8)5.2 (13.5)13,180.6 (31.3)13,303.3 (31.3)
  • a The coefficient of variation (percent) is given in parentheses. AUC, area under the curve; Cmax, maximum concentration, infinity. Significant difference is indicated as follows: *, P < 0.001 for mota-YTE compared with motavizumab; †, P < 0.01 for mota-YTE compared with motavizumab.