Table 5

In vitro sensitivity of P. falciparum to artesunate, chloroquine, dihydroartemisinin, mefloquine, piperaquine, and quinine in Cambodia

DrugaParameterbPailin, PailinVeal Veng, PursatRovieng, Preah VihearVeun Sai, Ratanakiri
2008/09, Jul–Mar2009/10, Sep–Mar2010/11, Aug–Jan2008/09, Jul–Jan2010, Aug–Dec2009/10, Sep–Dec2009/10, Oct–Feb2010, Aug–Sep
ASNo. of samples1921137934391349
Median IC50 (nM)1.72.21.82.31.61.22.91.0
IQR (nM)1.1–2.41.5–2.61.3–2.31.8–3.31.1–2.20.9–2.00.9–4.60.5–1.6
Range (nM)0.7–4.80.6–110.3–4.70.5–7.60.6–5.60.7–7.60.4–8.20.3–11
CQNo. of samples191797731361242
Median IC50 (nM)151150151168171835250
IQR (nM)102–216100–185124–205116–250124–25362–26237–9844–117
Range (nM)83–41156–23199–27645–62733–64925–67122–29918–320
DHANo. of samples1619128032341148
Median IC50 (nM)2.62.81.53.91.91.74.01.2
IQR (nM)1.9–3.22.1–5.21.0–2.52.4–5.71.1–2.61.3–2.21.3–5.50.7–1.5
Range (nM)0.9–6.41.1–100.4–3.50.7–110.4–4.20.5–5.40.4–110.2–4.1
MQNo. of samples1820117932371247
Median IC50 (nM)2724638555191323
IQR (nM)22–3820–4845–10871–11831–9613–448–2717–31
Range (nM)18–719–7824–1489–16911–2674–896–435–176
PIPNo. of samples161896730361246
Median IC50 (nM)6340318042303542
IQR (nM)40–10328–4729–4038–11529–5624–4731–3836–47
Range (nM)6.6–1255.0–6920–487.8–18917–824.0–7714–5115–107
QUNo. of samples191697730321144
Median IC50 (nM)2191993583803569269135
IQR (nM)159–350147–300230–513270–468180–51173–21061–10288–267
Range (nM)66–512127–508135–85269–112160–95826–89527–20543–822
  • a The in vitro sensitivities of P. falciparum to artesunate (AS), chloroquine (CQ), dihydroartemisinin (DHA), mefloquine (MQ), piperaquine (PIP), and quinine (QU) were evaluated.

  • b IQR, interquartile range.