Table 1

2-Aminopyridines and 2-aminopyrazines with in vitro activity against T. brucei subsp. brucei and selectivity over mammalian cell lines

Table 1
  • a IC50s and standard deviations reported in micromolar units and based on averages from two independent dose-response evaluations, except for 1a, 1l, and 2g, which are based on averages from triplicate independent dose-response evaluations.

  • b Selectivity window was calculated as the ratio of the IC50 against mammalian cells (using the lowest value obtained for MOLT4 or L929 cells) over the IC50 against T. brucei subsp. brucei in vitro.

  • c 1a, CBK3987; 1l, CBK3974; 2g, CBK201352.