Table 2

Numbers of M. tuberculosis CFU recovered from lungs and spleens of mice harvested after 28 days of a twice-weekly treatment starting 21 days postinfection

Treatment groupLog10 no. of CFU/g of tissue ± SDa
LungsSpleen
Group 1 (untreated control)6.11 ± 0.025.79 ± 0.08
Group 2 (inhalation of CFM-DPI at ∼240 μg)4.78 ± 0.215.19 ± 0.05
Group 3 (inhalation of CFM-DPI at ∼480 μg)3.97 ± 0.24*4.89 ± 0.10
Group 4 (inhalation of CFM-DPI at ∼720 μg)3.5 ± 0.65*4.76 ± 0.08
Group 5 (oral CFM at ∼125 μg)5.73 ± 0.164.60 ± 0.11
Group 6 (oral CFM at ∼250 μg)5.53 ± 0.264.43 ± 0.18
Group 7 (oral CFM at ∼500 μg)5.38 ± 0.254.39 ± 0.12
Group 8 (oral INH + RFB at ∼250μg each)3.83 ± 0.46*2.82 ± 0.92*
  • a *, significant difference at the 0.05 level from infected, untreated controls and from the 500-μg-oral-dose group.