Table 1

Phenotypic and genetic characteristics of a Neisseria gonorrhoeae strain with high-level resistance to spectinomycin identified in Norway

CharacteristicaResultb
MIC (resistance)c
    SPT>1,024 (R)
    CRO0.016 (S)
    CFM<0.016 (S)
    AZM0.125 (S)
    CIP0.125 (I)
SerovarByvu
NG-MASTST918
16S rRNA geneWT
Ribosomal protein 5SDeletion of valine (amino acid 25d) and an alteration of lysine to glutamic acid (amino acid 26d)
  • a For MIC data, Etest was used and only whole MIC dilutions are presented. NG-MAST, Neisseria gonorrhoeae multiantigen sequence typing; SPT, spectinomycin; CRO, ceftriaxone; CFM, cefixime; AZM, azithromycin; CIP, ciprofloxacin.

  • b ST, sequence type; WT, wild type.

  • c Susceptibility (S), intermediate susceptibility (I), and resistance (R) were determined based on the interpretative criteria stated by the Clinical and Laboratory Standards Institute (CLSI) (M100-S22).

  • d Escherichia coli (GenBank accession no. AAA58100) numbering that corresponds to amino acids 27 and 28, respectively, in the ribosomal protein 5S of Neisseria gonorrhoeae.