Table 1

Clinical methicillin-resistant Staphylococcus aureus strains used in this study

StrainDescriptionaVAN MIC (μg/ml)VAN response in IE modelb
300-087agrI, SCCmec IV, spa-NEW4, CC450.5Nonresponder
300-169agrI, SCCmec IV, spa-NEW1, CC450.5Nonresponder
324-136agrI, SCCmec IV, spa-NEW5, CC450.5Nonresponder
300-103agrI, SCCmec IV, spa-NEW4, CC450.5Nonresponder
300-246agrII, SCCmec I, spa-385, CC50.5Nonresponder
301-188agrI, SCCmec IV, spa-NEW1, CC450.5Responder
010-016agrII, SCCmec II, spa-2, CC51.0Responder
077-107agrII, SCCmec II, spa-2, CC51.0Responder
088-180agrII, SCCmec II, spa-2, CC50.5Responder
088-237agrII, SCCmec II, spa-2, CC50.5Responder
  • a CC, clonal complex.

  • b Vancomycin response in an experimental endocarditis (IE) model, as previously described (15). See Materials and Methods for further descriptions.