Table 3

Characteristics of C. jejuni mutants selected by Tyl

Lineagea and strainbMIC (μg/ml)Mutation in 23S rRNA geneChange in protein L4Change(s) in protein L22Mutation in cmeR
EryTyl
Parent, NCTC 1116814c
68Tx-1
    68T4-148A88E
    68T16-132256R72IA88EH174N
    68T32-164256R72IA88EH174N
    68T128-1128256R72IA88EH174N
68Tx-2
    68T4-248
    68T16-2128256G57V
    68T32-2256512G57VG86E
    68T128-2128256G57VG86E
68 Tx-3
    68T4-328
    68T16-332256A71DS117Y
    68T32-364512A71DA88ES117Y
    68T64-316256A71DA88ES117Y
68Tx-4
    68T4-428
    68T8-41664A71D
    68T16-432128A71DA88EG204L
    68T32-464256A71DA88EG204L
    68T64-4128512A71DA88E, G86VG204L
Parent, 8117614
76Tx-7
    76T8-7832
    76T16-732128G57DG86E
    76T32-764256G57DG86E
  • a See Table 2 footnote a for an explanation of the lineage names. T represents selection by Tyl.

  • b See Table 2 footnote b for an explanation of the strain names.

  • c —, no mutations detected.