Table 2

In vitro activity of benzoxaboroles against Gram-negative bacteriaa

OrganismMIC (μg/ml)
AN3334AN3016AN3365
E. coli K12 ΔlacU169 strain182
E. coli K12 ΔlacU16 tolC::Tn10 strain222
E. coli ATCC 25922141
E. coli ESBL (CTX-M-2, OXA-2)1161
K. pneumoniae 1534 (KPC-2)0.5161
E. cloacae BAA-1143 (AmpC+)180.5
P. mirabilis BAA-663 (TEM-89)>64321
P. aeruginosa PA012>641
P. aeruginosa PAM 1626 (pump)180.5
P. aeruginosa ATCC 278531>644
A. baumannii ATCC 15473>6441
  • a E. cloacae BAA-1143 (28) is a constitutive overproducer of the class C β-lactamase AmpC. P. aeruginosa PAM 1626 has the three major efflux pumps deleted (29).