Table 3

IC50 from different preincubation times and reactivation rate determinations for E. coli LeuRSa

CompoundIC50 (μM) by preincubation periodHalf-life of inhibition complex (min)
2 min20 min60 min
AN2679ND27.526.313
AN30161.52.11.855
AN33345.91.00.4360
AN32132.30.540.14963
AN33652.30.310.12ND
  • a ND, not determined.