Table 5

In vitro activity of AN3365 and comparators against multidrug-resistant Gram-negative bacteriaa

Organism (no. of isolates)MIC (μg/ml)
AN3365CiprofloxacinMeropenem
Range90%Range90%Range90%
A. baumannii (16)0.5–440.12–>64>644–>64>64
Enterobacteriaceae (18)0.5–22≤0.006–>6.4>6.4≤0.06–>6464
Enterobacteriaceae NDM-1 (16)0.5–220.03–>16b>16b≤0.0-6–>6464
P. aeruginosa (11)1–440.12–>64>640.25–>64>64
  • a MIC values were determined using M7-A7 CLSI guidelines for aerobic bacteria (27). The MIC90 is the concentration that inhibits 90% of the isolates.

  • b The fluoroquinolone levofloxacin was tested instead of ciprofloxacin; these compounds have similar activities and near-complete cross-resistance against Gram-negative bacteria. The levofloxacin and meropenem MIC values in the NDM-1 panel were determined by the agar dilution method of the British Society for Antimicrobial Chemotherapy.