Table 3

Dose and T>MIC values for stasis and 1-log kill and the maximum extent of killing with 6-hourly dosing of ceftolozane against four wild-type Enterobacteriaceae strains and four P. aeruginosa strainsa

OrganismStatic dose (mg/kg/6 h)T>MIC (%)1-Log kill dose (mg/kg/6 h)T>MIC (%)Maximal killing (log10 CFU/thigh)
Wild-type Enterobacteriaceae strains
    E. coli ATCC 2592238.728.175.632.8–2.95
    E. coli NIH-J5.6928.014.332.3–2.49
    K. pneumoniae ATCC 4381661.225.212732.0–2.52
    K. pneumoniae 21636.024.076.629.2–2.42
    Mean26.3 ± 2.131.6 ± 1.6–2.60 ± 0.24
P. aeruginosa strains
    P. aeruginosa ATCC 2785321.324.388.533.9–1.92
    P. aeruginosa 4034A41.528.511935.3–2.61
    P. aeruginosa PO212.221.750.530.1–2.24
    P. aeruginosa 31321.421.451.926.7–2.99
    Mean24.0 ± 3.331.5 ± 3.9–2.44 ± 0.46
Mean for all strains25.2 ± 2.831.5 ± 2.8–2.52 ± 0.35
  • a Mean values are expressed as means ± the standard errors of the mean.