Table 4

Change in log10 CFU/thigh (and lung) after 24 h of therapy with ceftolozane alone or in combination with tazobactam at ratios of 2:1, 4:1, and 8:1 against Enterobacteriaceae producing various ESBLs in neutropenic micea

OrganismControlCeftolozane dose (mg/kg)Change in log10 CFU/thigh after 24 h of therapy
CeftolozaneCeftolozane + TZB (2:1)Ceftolozane + TZB (4:1)Ceftolozane + TZB (8:1)
E. coli 60422.22 ± 0.17400–0.32 ± 0.56–1.91 ± 0.63–1.31 ± 0.21–1.15 ± 0.37
K. pneumoniae 41053.07 ± 0.104001.76 ± 0.30–0.21 ± 0.300.58 ± 0.351.28 ± 0.10
2.63 ± 0.378000.87 ± 0.77–1.44 ± 0.40–1.01 ± 0.250.53 ± 0.82
    Lung2.22 ± 0.504001.09 ± 0.85–0.60 ± 0.45–0.09 ± 0.220.41 ± 0.81
K. pneumoniae 41101.82 ± 0.104001.05 ± 0.071.03 ± 0.040.91 ± 0.081.01 ± 0.05
1.57 ± 0.248000.29 ± 0.12–0.53 ± 0.10–0.41 ± 0.230.33 ± 0.92
K. pneumoniae 81-1260A3.15 ± 0.07400–0.87 ± 0.41–2.33 ± 0.50–1.59 ± 0.86–1.08 ± 0.57
E. cloacae 81-1291A2.04 ± 0.09400–1.06 ± 0.30–3.05 ± 0.37–3.29 ± 0.57–2.78 ± 0.30
  • a Values are expressed as means ± the standard error of the mean where applicable.