Table 3

Parameter estimates with relative standard errors of the final modela

Fixed effectsbValue (RSE, %)Random effectsValue, % CV (RSE, %)
MTT, h1.31 (12.6)BOV F23.6 (26.9)
KA, h−10.128 (8.7)BSV F24.3 (28)
CL, liters h−12.96 (9.5)BOV MTT55.4 (11)
V, liters17.3 (18.7)BSV CL23.7 (11.9)
Q1, liters h−15.01 (8.3)BSV CLM229.6c (31.5), 18.8 (23.7)
VP1, liters2,870 (15.3)BSV CLM3−12.9c (90.8), 71.3c (34.5), 30 (24.9)
Q2, liters h−14.16 (10.2)BSV EFVEFF-BDQ−69.2c (13.8), −56.1c (24.1), −22.4c (64.7), 20.6 (10.8)
VP2, liters136 (9)BSV EFVEFF-M2−29.7c (36.6), −77c (29.5), −71.9c (32.8), 75.2c (17), 28.2 (22.1)
CLM2, liters h−112.3 (10.1)BSV EFVEFF-M3−7.4c (163.5), −58.2c (43.2), −83.4c (30.3), 42.5c (35.2), 87.9c (27.2), 32.7 (25)
VM2, liters659 (7.2)BSV V34.6 (32)
Q1M2, liters h−1103 (10.5)BSV Q118.7 (15)
VP1M2, liters2,840 (6)BSV VM228.9 (19)
CLM3, liters h−139.2 (9)BSV VP1M225.9 (39)
VM3, liters11.2 (44.7)
QM3, liters h−1106 (9.9)Prop error BDQ23.9 (5.3)
VPM3, liters2,680 (13.6)Prop error M214.9c (6.1), 17.7 (4.8)
EFVEFF BDQ and M22.07 (3.6)Prop error M37.5c (21.4), 11.7c (5.6), 15 (10.2)
EFVEFF M31.12 (3.6)
NN5.21 (20.5)
Error wt TAD < 6 h1.87 (11)
Error wt < BLQ3.28 (15)
  • a Abbreviations: MTT, mean transit time; KA, absorption rate constant; F, bioavailability; CL, clearance, V, volume of distribution; Q, intercompartmental clearance; VP, volume of distribution of peripheral compartments; EFVEFF, induction effect of EFV; NN, number of transit compartments; TAD, time after dose; BLQ, below limit of quantification; Prop, proportional; BOV, between-occasion variability; BSV, between-subject variability; RSE, relative standard error; % CV, percent coefficient of variation.

  • b Estimated with typical value of F fixed to 1.

  • c Correlation estimated as a covariance; presented here structured as the omega or sigma blocks used in the NONMEM code.