Table 2

Parameter values from the mathematical model for each isolatea

ParameterbH99F/13186F/6317F/20886
MedianSDMedianSDMedianSDMedianSD
Ka (h−1)0.871.011.321.591.071.031.31.88
SCL/F (liter/h)0.0050.00260.0070.0030.0050.0030.0050.003
Vc/F (liter)0.0070.00070.010.0020.010.010.010.003
kcp (h−1)14.476.1210.855.033.472.3614.224.61
kpc (h−1)12.448.0218.912.9427.421.6619.778.49
kcb (h−1)24.635.3515.595.8223.634.8321.665.5
kbc (h−1)13.294.7714.713.2814.275.4916.556.05
Vbrain/F (liter)0.0280.0090.020.0160.0360.0050.030.009
Kgmax (log10 CFU/g/h)0.0770.0180.0840.0070.0410.00020.0881.83
Hg8.430.331.572.5719.260.526.6550.92
C50g (mg/liter)3.631.772.495.334.761.221.620.01
POPMAX (CFU/g of cerebrum)11,370,0006,811,080542,10827,605,8001,147,144406,2189,888,7723,562,500
Kkmax (log10 CFU/g/h)0.0320.010.0190.030.0170.0030.0250.013
Hk1.1290.0591.180.0511.070.331.293.39
C50k (mg/liter)21.066.3916.4410.2815.551.3738.4213.81
Initial condition (CFU/g of cerebrum)317.87139.2489.0746.39101.291.2339.98131.34
  • a The estimated parameter values and standard deviations from the mathematical models fitted to each of the strains.

  • b See text for a definition of the parameters. F, bioavailability.