Table 1

Enzyme combinations detected among Enterobacteriaceae strains collected from U.S. hospitals during 2010

β-LactamasesNo. of isolatesState(s) (no. of isolates)Bacterial species (no. of isolates)
Combinations including carbapenemases
    KPC-2, CTX-M-15, SHV-1, TEM-13Texas (3)K. pneumoniae (3)
    KPC-2, OXA-2, OXY-2-41Virginia (1)K. oxytoca (1)
    KPC-2, SHV-1, TEM-12New York (1), Texas (1)K. pneumoniae (2)
    KPC-2, SHV-111New York (1)K. pneumoniae (1)
    KPC-2, SHV-11, TEM-15Texas (5)K. pneumoniae (5)
    KPC-2, TEM-14Massachusetts (2), New York (1), Virginia (1)E. cloacae (3), K. pneumoniae (1)
    KPC-3, CTX-M-15, OXA-1/30, SHV-11, TEM-11New York (1)K. pneumoniae (1)
    KPC-3, SHV-11, TEM-19Michigan (3), New Jersey (2), New York (4)K. pneumoniae (9)
    KPC-3, SHV-12, TEM-11Virginia (1)E. cloacae (1)
    KPC-3, TEM-11New Jersey (1)E. cloacae (1)
Combinations including ESBLs
    CTX-M-14, SHV-11, TEM-12Wisconsin (2)K. pneumoniae (2)
    CTX-M-14, SHV-63, TEM-11Florida (1)K. pneumoniae (1)
    CTX-M-14, TEM-14Colorado (1), Michigan (1), New York (2)E. coli (4)
    CTX-M-15, OXA-1/3017Colorado (1), Florida (2), Hawaii (1), Kentucky (1), Michigan (3), New Jersey (1), New York (5), Texas (1), Virginia (2)E. coli (17)
    CTX-M-15, OXA-1/30, PSE-likea1Nebraska (1)E. coli (1)
    CTX-M-15, OXA-1/30, SHV-11New York (1)K. pneumoniae (1)
    CTX-M-15, OXA-1/30, SHV-1, TEM-12Indiana (1), New York (1)K. pneumoniae (2)
    CTX-M-15, OXA-1/30, SHV-11, TEM-14Kentucky (1), New York (2), Ohio (1)K. pneumoniae (4)
    CTX-M-15, OXA-1/30, TEM-16Iowa (1), Michigan (3), New York (1), Ohio (1)E. coli (6)
    CTX-M-15, SHV-13Kentucky (1), New Jersey (1), Texas (1)K. pneumoniae (3)
    CTX-M-15, SHV-1, TEM-19Michigan (1), New Jersey (1), Texas (7)K. pneumoniae (8), S. marcescens (1)
    CTX-M-15, SHV-112Michigan (2)K. pneumoniae (2)
    CTX-M-15, TEM-18Florida (1), Kentucky (1), Massachusetts (1), Nebraska (1), New York (2), Utah (1), Vermont (1)E. coli (8)
    CTX-M-27, OXA-1/301New York (1)E. coli (1)
    CTX-M-27, SHV-11, TEM-12Massachusetts (1), New York (1)E. coli (1), K. pneumoniae (1)
    CTX-M-27, TEM-11Vermont (1)E. coli (1)
    CTX-M-91, TEM-11New Jersey (1)P. mirabilis (1)
    PER-1, SHV-12, TEM-11New York (1)P. vulgaris (1)
    SHV-2, TEM-11Kentucky (1)K. pneumoniae (1)
    SHV-2, SHV-1, SHV-1411Massachusetts (1)K. pneumoniae (1)
    SHV-2, SHV-1, SHV-1531Kentucky (1)K. pneumoniae (1)
    SHV-5, SHV-1, SHV-149, SHV-150, SHV-151, SHV-154, SHV-161, OXA-1/30, TEM-11New York (1)K. pneumoniae (1)
    SHV-5, SHV-1, SHV-11, SHV-147, SHV-148, OXA-2, TEM-11New York (1)K. pneumoniae (1)
    SHV-5, SHV-751New York (1)K. pneumoniae (1)
    SHV-5, SHV-11, TEM-11Ohio (1)K. pneumoniae (1)
    SHV-7, OXA-2, TEM-12Kentucky (2)E. cloacae (2)
    SHV-7,OXA-9, TEM-11Virginia (1)E. coli (1)
    SHV-7, TEM-11Virginia (1)E. coli (1)
    SHV-12, OXY-2-12, TEM-11Ohio (1)K. oxytoca (1)
    SHV-12, SHV-111New Jersey (1)K. pneumoniae (1)
    SHV-12, SHV-11, SHV-141, SHV-161, SHV-163, TEM-11Massachusetts (1)K. pneumoniae (1)
    SHV-12, SHV-11, SHV-155, SHV-156, SHV-1601Ohio (1)K. pneumoniae (1)
    SHV-12, SHV-11, SHV-158, SHV-1591New York (1)K. pneumoniae (1)
    SHV-12, SHV-11, TEM-11Massachusetts (1)K. pneumoniae (1)
    SHV-12, TEM-15Arkansas (1)E. coli (1), E. coli (1), K. pneumoniae (3)
    TEM-155, SHV-111New York (1)K. pneumoniae (1)
Combinations including acquired cephalosporinases
    CMY-2, CTX-M-141New York (1)E. coli (1)
    CMY-2, SHV-331Vermont (1)K. pneumoniae (1)
    CMY-2, TEM-15Colorado (1), Kentucky (1), Michigan (1), New Jersey (1), Texas (1)E. coli (5)
    CMY-like,b TEM-11Iowa (1)E. coli (1)
    DHA-1, TEM-11Hawaii (1)P. mirabilis (1)
    FOX-5, PSE-likea3Florida (1), Massachusetts (1), Virginia (1)E. cloacae (1), K. pneumoniae (1), P. mirabilis (1)
    FOX-5, SHV-111Wisconsin (1)K. pneumoniae (1)
    FOX-5, PSE-like,a SHV-111Kentucky (1)K. pneumoniae (1)
  • a blaPSE sequencing coverage did not allow differentiation of PSE-1 and PSE-4.

  • b New CMY variant similar to CMY-55.