Table 2

IC50s of drugs showing activity in the assays compared to their reported IC50s against asexual parasitesa

DrugIC50 (nM)
Male assayFemale assayAsexual parasites
Pyronaridine2,7001,8314.9
Methylene blue2019413.62
Thiostrepton961,427387.7
Pyrimethamine8.7>10,00017
Cycloguanil124>10,0004.5
Artemisinin224>10,0005.8
Dihydroartemisinin85>10,0001.1
Artesunate483>10,0003.5
  • a Asexual data were all obtained from NF54 parasites as reported by Delves et al. (3), except the IC50 of methylene blue, which represents the geometric mean for 23 P. falciparum isolates as reported by Pascual et al. (44).