Table 2

Effect of AC17 with fluconazole in a guinea pig model of cutaneous candidiasis

Test compound(s)Dose(s) (%)cEfficacy (%)Mean tissue burden (log CFU/g tissue) ± SD
Fluconazole0.00526.52.24 ± 1.11
AC17222.63.26 ± 0.52
Fluconazole + AC170.005 + 260.8a,b1.49 ± 0.90a
Untreated controlNA3.58 ± 0.73
  • a P value of <0.05 compared to the untreated control.

  • b P value of <0.05 compared to fluconazole alone.

  • c NA, not applicable.