Table 1

MICs of β-lactams for P. aeruginosa NCGM1496 and NCGM1663 and E. coli strains transformed with IMP-7, IMP-43, IMP-11, and IMP-44

Antibiotic(s)aMIC (μg/ml)
P. aeruginosa NCGM1496P. aeruginosa NCGM1663E. coli DH5α(pHSG398/IMP-7)E. coli DH5α(pHSG398/IMP-43)E. coli DH5α(pHSG398/IMP-11)E. coli DH5α(pHSG398/IMP-44)E. coli DH5α(pHSG398)
Ampicillin>512>5121683282
Ampicillin-sulbactam>512>512841641
Aztreonam3264<0.25<0.25<0.25<0.25<0.25
Cefepime>512>512441616<0.25
Cefmetazole>512>51225632256641
Cefoselis>512>51288324<0.25
Cefotaxime>512>5123232128128<0.25
Cefoxitin>512>512512645121282
Cefozopran512>512883232<0.25
Cefpirome64>512323241<0.25
Cefsulodin>512>512>512>512>512>512256
Ceftazidime>512>512512512256256<0.25
Ceftriaxone>512>5126464128256<0.25
Cefuroxime>512>512512512512>5124
Cephradine>512>51251251251212816
Doripenem>512>5120.52832<0.25
Imipenem>512>5120.50.528<0.25
Meropenem>512>5120.521664<0.25
Moxalactam>512>512256256256>512<0.25
Panipenem>512>51211216<0.25
Penicillin G>512>5123232643232
Piperacillin646422422
Piperacillin-tazobactam323222111
Ticarcillin256>512512645121282
Ticarcillin-clavulanic acid256>512256645121282
  • a The ratio of ampicillin to sulbactam was 2:1. The ratio of piperacillin to tazobactam was 4:1. The ratio of ticarcillin to clavulanic acid was 15:1.