TABLE 3

Clinical outcomes for patients with S. maltophilia infections who received monotherapy with FQ or SXT

OutcomeValueaP valuec
Overall (n = 98)FQ (n = 63)SXT (n = 35)
Levofloxacin (n = 48)Ciprofloxacin (n = 15)P valuebTotal (n = 63)
Microbiological cure at EOT36/57 (63)18/30 (60)5/7 (71)0.6923/37 (62)13/20 (65)0.83
    Urine8/8 (100)5/5 (100)1/1 (100)6/6 (100)2/2 (100)
    Skin/skin structure6/7 (86)2/3 (67)1/1 (100)1.03/4 (75)3/3 (100)1.00
    Intra-abdominal4/5 (80)0/0 (0)2/2 (100)2/2 (100)2/3 (67)1.00
    Pulmonary16/32 (50)10/19 (53)0/2 (0)0.4810/21 (48)6/11 (55)0.71
    Bacteremia2/5 (40)1/3 (33)1/1 (100)1.02/4 (50)0/1 (0)1.00
In-hospital mortality23 (24)15/48 (31)1/15 (7)0.0916 (25)7 (20)0.55
    Bacteremia2/6 (33)2/4 (50)0/1 (0)1.00/1 (0)2/5 (40)1.00
    Pulmonary17/55 (31)11/32 (34)1/6 (17)0.6412/38 (32)5/17 (29)0.87
    Urine2/9 (22)1/5 (20)0/1 (0)1.01/6 (17)1/3 (33)1.00
    Intra-abdominal1/9 (11)1/2 (50)0/3 (0)0.401/5 (20)0/4 (0)1.00
    Skin/skin structure1/19 (5)0/5 (0)0/4 (0)0/9 (0)1/10 (10)1.00
30-day mortality22/79 (28)14/39 (36)2/13 (15)0.3016/52 (31)6/27 (22)0.42
    Pulmonary18/45 (40)11/27 (41)2/5 (40)1.013/32 (41)5/13 (39)0.89
    Urine2/7 (29)1/4 (25)0/1 (0)1.01/5 (20)1/2 (50)1.00
    Bacteremia1/5 (20)1/4 (25)0/1 (0)1.01/5 (20)
    Intra-abdominal1/6 (17)1/1 (100)0/2 (0)0.331/3 (33)0/3 (0)1.00
    Skin/skin structure0/16 (0)0/3 (0)0/4 (0)0/7 (0)0/9 (0)
Clinical success at EOT44/80 (55)20/42 (48)7/10 (70)0.3027/52 (52)17/28 (61)0.45
    Urine7/9 (78)4/5 (80)1/1 (100)1.05/6 (83)2/3 (67)1.00
    Skin/skin structure9/14 (64)1/2 (50)3/3 (100)0.404/5 (80)5/9 (56)0.58
    Intra-abdominal4/7 (57)0/2 (0)0/1 (0)0/3 (0)4/4 (100)0.03
    Pulmonary22/44 (50)14/29 (48)2/4 (50)1.016/33 (49)6/11 (55)0.73
    Bacteremia2/6 (33)1/4 (25)1/1 (100)0.402/5 (40)0/1 (0)1.00
Nonsusceptible isolate within 30 days of EOT15/57 (26)9/30 (30)2/7 (29)1.011/37 (30)4/20 (20)0.43
    Bacteremia2/5 (40)2/3 (67)0/1 (0)1.02/4 (50)0/11.00
    Pulmonary12/32 (38)6/19 (32)2/2 (100)0.138/21 (38)4/11 (36)1.00
    Skin/skin structure1/7 (14)1/3 (33)0/1 (0)1.01/4 (25)0/3 (0)1.00
    Urine0/8 (0)0/5 (0)0/1 (0)0/6 (0)0/2 (0)
    Intra-abdominal0/5 (0)0/0 (0)0/2 (0)0/2 (0)0/3 (0)
  • a All values shown as number/total (percent).

  • b P value comparing patients who received levofloxacin to patients who received ciprofloxacin.

  • c P value comparing patients who received trimethoprim-sulfamethoxazole to patients who received a fluoroquinolone.