TABLE 1

Position of the mutation in the reference gene which leads to antibiotic resistance in different chromosomal genes

GeneaMutational point(s)Reference sequence (5′–3′)b
rpoBC1564(64)A:A1565(65)T:A1565(65)G:G1573(73)T:A1574(74)T:C1603(103)G:C1603(103)T:A1604(104)T:C1619(119)A:C1619(119)T:C1696(196)T:A1741(241)T1501(1):TTGATTAATGCAAAACCAGTTGCTGCTGCAATCAAAGAATTCTTTGGTTCAAGCCAGTTATCTCAGTTTATGGACCAAAACAACCCACTATCTGAGATTACACATAAACGTCGTGTATCTGCGCTTGGTCCTGGTGGTTTAACACGTGAACGTGCGGGCTTCGAAGTACGTGACGTACACCAAACTCACTATGGTCGTGTTTGTCCAATTGAAACTCCTGAAGGTCCAAACATTGGTTTGATCAACTCGCTTTCTGTATACGCAAAAGCGAATGACTTCGGTTTCTTGGAAACTCCATAC:1800(300)
gyrA1T175(175)A:G224(224)C:C198(198)T:G259(259)T:G259(259)A1(1):ATGAGCGACCTTGCGAGAGAAATTACACCGGTCAACATTGAGGAAGAGCTGAAGAGCTCCTATCTGGATTATGCGATGTCGGTCATTGTTGGCCGTGCGCTGCCAGATGTCCGAGATGGCCTGAAGCCGGTACACCGTCGCGTACTTTACGCCATGAACGTACTAGGCAATGACTGGAACAAAGCCTATAAAAAATCTGCCCGTGTCGTTGGTGACGTAATCGGTAAATACCATCCCCATGGTGACTCGGCGGTCTATGACACGATCGTCCGCATGGCGCAGCCATTCTCGCTGCGTTAT:300(300)
gyrA2G2599(299)T2301(1):GACGAAAGGGGTTATCTCCATCAAGGTTACCGAACGTAACGGTTTAGTTGTTGGCGCGGTACAGGTAGATGACTGCGACCAGATCATGATGATCACCGATGCCGGTACGCTGGTACGTACTCGCGTTTCGGAAATCAGCATCGTGGGCCGTAACACCCAGGGCGTGATCCTCATCCGTACTGCGGAAGATGAAAACGTAGTGGGTCTGCAACGTGTTGCTGAACCGGTTGACGAGGAAGATCTGGATACCATCGACGGCAGTGCCGCGGAAGGGGACGATGAAATCGCTCCGGAAGTGGA:2600(300)
parCG233(33)A:A238(38)C:G239(39)T:C240(40)A:G250(50)A: A682(482)G:G757(557)A201(1):CGGTGACGTACTGGGTAAATACCATCCGCACGGCGATAGCGCCTGTTATGAAGCGATGGTCCTGATGGCGCAACCGTTCTCTTACCGTTATCCGCTGGTTGATGGTCAGGGGAACTGGGGCGCGCCGGACGATCCGAAATCGTTCGCGGCAATGCGTTACACCGAATCCCGGTTGTCGAAATATTCCGAGCTGCTATTGAGCGAGCTGGGGCAGGGGACGGCTGACTGGGTGCCAAACTTCGACGGCACTTTGCAGGAGCCGAAAATGCTACCTGCCCGTCTGCCAAACATTTTGCTTAACGGCACCACCGGTATTGCCGTCGGCATGGCGACCGATATTCCACCGCATAACCTGCGTGAAGTGGCTCAGGCGGCAATCGCATTAATCGACCAGCCGAAAACCACGCTCGATCAGCTGCTGGATATCGTGCAGGGGCCGGATTATCCGACTGAAGCGGAAATTATCACTTCGCGCGCCGAGATCCGTAAAATCTACGAGAACGGACGTGGTTCAGTGCGTATGCGCGCGGTGTGGAAGAAAGAAGATGGCGCGGTGGTTATCAGCGCATTGCCGCATCAGGTTTCAGGTGCGCGCGTACT:800(600)
16S rRNAT1406(206)A:A1408(208)G:C1409(209)T:G1491(291)T1201(1):ATCATGGCCCTTACGACCAGGGCTACACACGTGCTACAATGGCGCATACAAAGAGAAGCGACCTCGCGAGAGCAAGCGGACCTCATAAAGTGCGTCGTAGTCCGGATTGGAGTCTGCAACTCGACTCCATGAAGTCGGAATCGCTAGTAATCGTGGATCAGAATGCCACGGTGAATACGTTCCCGGGCCTTGTACACACCGCCCGTCACACCATGGGAGTGGGTTGCAAAAGAAGTAGGTAGCTTAACCTTCGGGAGGGCGCTTACCACTTTGTGATTCATGACTGGGGTGAAGTCGTAA:1500(300)
23S rRNAA2058(8)G:A2059(9)G:C2611(561)T2051(1):AAGACGGAAAGACCCCGTGAACCTTTACTATAGCTTGACACTGAACATTGAGCCTTGATGTGTAGGATAGGTGGGAGGCTTTGAAGTGTGGACGCCAGTCTGCATGGAGCCGACCTTGAAATACCACCCTTTAATGTTTGATGTTCTAACGTTGACCCGTAATCCGGGTTGCGGACAGTGTCTGGTGGGTAGTTTGACTGGGGCGGTCTCCTCCTAAAGAGTAACGGAGGAGCACGAAGGTTGGCTAATCCTGGTCGGACATCAGGAGGTTAGTGCAATGGCATAAGCCAGCTTGACTGCGAGCGTGACGGCGCGAGCAGGTGCGAAAGCAGGTCATAGTGATCCGGTGGTTCTGAATGGAAGGGCCATCGCTCAACGGATAAAAGGTACTCCGGGGATAACAGGCTGATACCGCCCAAGAGTTCATATCGACGGCGGTGTTTGGCACCTCGATGTCGGCTCATCACATCCTGGGGCTGAAGTAGGTCCCAAGGGTATGGCTGTTCGCCATTTAAAGTGGTACGCGAGCTGGGTTTAGAACGTCGTGAGACAGTTCGGTCCCTATCTGCCGTGGGCGCTGGAGAACTGAGGGGGGCTGCT:2650(300)
katGG871(171)A:G900(200)C:G944(244)C:G985(285)GG701(1):GGCCGAACGGCAACCCGGACCCCATGGCCGCGGCGGTCGACATTCGCGAGACGTTTCGGCGCATGGCCATGAACGACGTCGAAACAGCGGCGCTGATCGTCGGCGGTCACACTTTCGGTAAGACCCATGGCGCCGGCCCGGCCGATCTGGTCGGCCCCGAACCCGAGGCTGCTCCGCTGGAGCAGATGGGCTTGGGCTGGAAGAGCTCGTATGGCACCGGAACCGGTAAGGACGCGATCACCAGCGGCATCGAGGTCGTATGGACGAACACCCCGACGAAATGGGACAACAGTTTCCTCG:1000(300)
pncAA139(39)G:T192(92)TA1(1):ATGCGGGCGTTGATCATCGTCGACGTGCAGAACGACTTCTGCGAGGGTGGCTCGCTGGCGGTAACCGGTGGCGCCGCGCTGGCCCGCGCCATCAGCGACTACCTGGCCGAAGCGGCGGACTACCATCACGTCGTGGCAACCAAGGACTTCCACATCGACCCGGGTGACCACTTCTCCGGCACACCGGACTATTCCTCGTCGTGGCCACCGCATTGCGTCAGCGGTACTCCCGGCGCGGACTTCCATCCCAGTCTGGACACGTCGGCAATCGAGGCGGTGTTCTACAAGGGTGCCTACACC:300(300)
embBA916(16)G:A916(16)C:G918(18)T:G918(18)A:G918(18)C901(1):GGCTACATCCTGGGCATGGCCCGAGTCGCCGACCACGCCGGCTACATGTCCAACTATTTCCGCTGGTTCGGCAGCCCGGAGGATCCCTTCGGCTGGTATTACAACCTGCTGGCGCTGATGACCCATGTCAGCGACGCCAGTCTGTGGATGCGCCTGCCAGACCTGGCCGCCGGGCTAGTGTGCTGGCTGCTGCTGTCGCGTGAGGTGCTGCCCCGCCTCGGGCCGGCGGTGGAGGCCAGCAAACCCGCCTACTGGGCGGCGGCCATGGTCTTGCTGACCGCGTGGATGCCGTTCAACAAC:1200(300)
rpsLA128(128)G:A263(263)G1(1):ATGGCAACAGTTAACCAGCTGGTACGCAAACCACGTGCTCGCAAAGTTGCGAAAAGCAACGTGCCTGCGCTGGAAGCATGCCCGCAAAAACGTGGCGTATGTACTCGTGTATATACTACCACTCCTAAAAAACCGAACTCCGCGCTGCGTAAAGTATGCCGTGTTCGTCTGACTAACGGTTTCGAAGTGACTTCCTACATCGGTGGTGAAGGTCACAACCTGCAGGAGCACTCCGTGATCCTGATCCGTGGCGGTCGTGTTAAAGACCTCCCGGGTGTTCGTTACCACACCGTACGTGGT:300(300)
pmrAG305(155)A151(1):GAGTTGCTTGCCCGTATTCATGCCTTACTACGCCGTAGTGGAGTAGAAGCTCAACTTGCGAGTCAAGATCAACTATTAGAAAGTGGTGATCTGGTTTTAAATGTTGAACAGCATATTGCGACGTTTAAAGGCCAACGCATTGATTTATCAAATCGTGAATGGGCAATCTTTYKAATTCCACTTATGACTCACCCAAATAAAATCTTTTCTAAAGCCAACTTAGAAGATAAGTTATATGATTTTGATAGTGATGTGACCAGTAATACTATTGAAGTATATGTTCACCATTTAAGAGCGAAG:450(300)
pmrB1C38(38)A:C41(41)T:G261(261)C:G261(261)T1(1):GTGCATTATTCATTAAAAAAACGACTGATTTGGGGCACCTCAATTTTCAGTGTCATCTTAGGTTGTATTTTAATTTTTAGTGCTTATAAGGTTGCACTTCAAGAAGTCGATGAAATTCTAGATACTCAAATGAAGTATTTAGCGGAAAGAACAGCTGAGCACCCTTTAAAAACTGTAAGCAGTAAGTTTGATTTTCATAAAACTTACCACGAAGAAGATCTGTTTATCGATATCTGGGCTTATAAGGATCAGGCCCATTTGTCTCATCATTTACATTTGCTGGTTCCACCTGTTGAGCAA:300(300)
pmrB2T434(14)A:C680(260)T:C697(277)T:C697(277)A:G784(364)C321(1):CTTGCGGGCAGTATGTTTATTCCGTATTTAATTATTTTACCTTTTGCAATATTTGCCTTAGCAGCCATTATTCGTCGTGGTTTAAAACCAATAGATGATTTTAAAAATGAGTTAAAAGAACGCGATTCCGAAGAACTCACACCAATTGAAGTACATGATTATCCTCAAGAGCTTTTACCTACTATTGACGAAATGAACCGTCTTTTTGAGCGCATTTCTAAAGCGCAAAATGAACAGAAGCAATTTATTGCCGATGCTGCTCATGAATTACGAACACCTGTGACTGCATTGAACTTACAAACCAAGATTTTGCTAAGCCAGTTTCCTGAGCATGAATCATTGCAAAACTTAAGCAAGGGTTTGGCGCGTATTCAGCATTT:700(380)
pmrB3T1057(7)A:T1160(110)A:C1208(158)T1051(1):GTTATTAATATTTCAGTTTATACCGATCCAGATCACTACGCATGTATTCAAATTGAAGATAGCGGTGCAGGAATAGACCCTGAAAATTACGATAAAGTCCTTAAGCGTTTTTATCGCGTGCATCACCATCTTGAGGTGGGAAGTGGTCTAGGTTTATCTATTGTAGATCGTGCAACTCAAAGGCTTGGTGGGACTTTAACTCTCGATAAGAGCTTAGAGCTTGGCGGTCTTTCTGTATTAGTGAAATTAC:1300(250)
  • a The nucleotide sequences for gyrA, parC, rpsL, 16s rRNA, and 23s rRNA were obtained from Escherichia coli sp. strain K-12 substrain MG1655; for rpoB, pmrA, and pmrB genes from Acinetobacter baumannii 17978; and for katG, pncA, and embB genes from Mycobacterium tuberculosis H37Rv.

  • b The first number and the second number in parentheses represent the nucleotide position of the reference gene in NCBI GenBank and the nucleotide position in the table, respectively.