TABLE 1

Baseline characteristics by treatment group

CharacteristicaValue(s) for group treated withb:P value
DHA-PIP (n = 47)Placebo (n = 22)
Male gender, no. of subjects (%)47 (100)22 (100)
Age (yr)26.70 (7.51)27.27 (7.60)0.7704
Military occupation, no. of subjects (%)47 (100)22 (100)
Tobacco user, no. of subjects (%)2 (4.26)1 (4.55)1.00
Ht (cm)165.1 (5.1)164.1 (5.5)0.4567
Wt (kg)61.4 (7.3)57.7 (5.4)0.0411
Predose vital signs
    Tympanic temp (°C)37.1 (0.3)37.2 (0.3)0.2583
    Pulse rate (beats/min)73 (10)72 (9)0.5823
    Systolic blood pressure (mm Hg)118 (9)116 (10)0.5030
    Diastolic blood pressure (mm Hg)71 (9)71 (10)0.8624
Hemoglobin (g/dl)14.1 (3.0)14.1 (3.3)0.6754
    % abnormal (range, 14–18 g/dl)28270.9733
MCV (fl)81 (8)81 (10)0.7900
RDW (%)11.8 (2.8)11.7 (3.7)0.2651
BUN (mg/dl)10.52 (4.11)9.32 (5.01)0.4092
    % abnormal (range, 8–21 mg/dl)10
Creatinine (mg/dl)0.932 (0.131)0.947 (0.134)0.6500
    % abnormal (range, 0.7–1.3 mg/dl)00
Potassium (meq/liter)3.84 (0.51)3.84 (0.30)0.7621
    % abnormal (range, 3.5–5.3 meq/liter)1514
Magnesium (mg/dl)1.9 (0.3)1.7 (0.5)0.2148
    % abnormal (range, 1.9–2.5 mg/dl)126
Calcium (mg/dl)8.4 (2.0)8.1 (2.3)0.4404
    % abnormal (range, 8.1–10.4 mg/dl)00
TSH (μIU/ml)1.29 (0.54)1.54 (0.71)0.1053
    % abnormal (range, 0.35–4.94 μIU/ml)00
  • a MCV, mean corpuscular volume; RDW, red blood cell distribution width; BUN, blood urea nitrogen; TSH, thyroid-stimulating hormone.

  • b Values for the groups given dihydroartemisinin-piperaquine (DHA-PIP) or placebo. All values are presented as means with the standard deviations (SDs) in parentheses unless otherwise stated.