TABLE 1

Analysis of the partial reversion of the phenotype of the AmB-resistant strain using an ascorbate peroxidase inhibitor

Exptl setLD50 (μg/ml)aFold decrease from value for strain without aminotriazole
Resistant strain + AmB0.837
Sensitive strain + AmB0.125
Sensitive overexpression strain + AmB0.631
Resistant strain + AmB + aminotriazole0.43∼1.9
Sensitive strain + AmB + aminotriazole0.124∼1.02
Sensitive overexpression strain + AmB + aminotriazole0.37∼1.70
  • a The LD50s of AmB in the presence and absence of different inhibitors were calculated from in vitro drug sensitivity assays as described in Materials and Methods.