TABLE 4

Monte Carlo simulation analysis examining AUC0–24 and trough achievementa

AUC/trough achievementResult by dosage for PMA and serum creatinine level of:
28 wk, 0.8 mg/dl34 wk, 0.4 mg/dl40 wk, 0.4 mg/dl46 wk, 0.4 mg/dl
20 mg/kg every 24 h15 mg/kg every 12 h15 mg/kg every 12 h20 mg/kg every 12 h20 mg/kg every 12 h15 mg/kg every 8 h15 mg/kg every 8 h15 mg/kg every 6 h
Target trough concn predictive of AUC0–24 of >400 in >90% of neonates (mg/liter)871199111110
% achieving target trough concn4199185625462982
% AUC0–24 > 40073>99469061806195
% trough concn ≥20 mg/liter13914<15219
  • a n = 5,000 per simulation.