TABLE 1

Drug susceptibilities of actively replicating versus oxygen-starved M. tuberculosisa

DrugMIC (μM) for M. tuberculosis
ReplicatingNonreplicating
RIF0.051.41
SQ1092.373.35
AU12350.31>310
THPP-26.25>25
  • a The MICs of RIF, SQ109, and AU1235 determined in the MABA and LORA assays (28, 29) are against virulent M. tuberculosis H37Rv. The MICs of THPP-2 are against M. tuberculosis H37Rv mc26206. The susceptibility of the actively replicating M. tuberculosis cells to this compound was determined in 7H9-OADC-Tween 80 broth using the resazurin microplate reduction assay, while that of the hypoxic nonreplicating bacilli was determined in Dubos Tween albumin medium, as described by Wayne and Hayes (26). The nonreplicating M. tuberculosis bacilli were exposed to THPP-2 for 7 days.