TABLE 2

Virologic and biochemical response during rescue therapy by genotypic resistance profile

Outcome and time pointValue for groupP value
LAM/ETV-R (n = 45)LAM/ADV-R (n = 28)LAM/ETV/ADV-R (n = 20)
Virologic
    Change in HBV DNA (log10 IU/ml)a
        3 mo−2.86 (−4.83 to 2.90)−2.30 (−4.83 to −0.67)−2.10 (−3.50 to −0.05)0.008
        6 mo−3.02 (−5.82 to 1.73)−2.52 (−5.84 to −1.04)−2.48 (−4.66 to −1.02)0.719
        12 mo−3.19 (−6.43 to −1.72)−2.48 (−5.84 to −1.14)−2.51 (−4.73 to −1.18)0.377
    Complete virologic suppression (undetectable HBV DNA)b0.072c
        3 mo31.1 (45)50.0 (28)30.0 (20)
        6 mo55.7 (45)75.0 (28)65.0 (20)
        9 mo58.1 (32)86.6 (23)88.3 (18)
        12 mo67.8 (18)93.3 (19)88.3 (16)
        24 mo82.8 (2)NAd88.3 (2)
Biochemical (normalization of serum ALT)b0.003c
    3 mo5.9 (17)50.0 (6)50.0 (6)
    6 mo23.5 (17)50.0 (6)50.0 (6)
    9 mo30.5 (15)83.3 (3)50.0 (6)
    12 mo44.5 (11)100.0 (2)83.3 (6)
  • a Data are medians, with ranges in parentheses.

  • b Data are cumulative probabilities of the response at the indicated time points, based on the Kaplan-Meier method, with the number of patients under observation in parentheses.

  • c The log rank test was used to compare the hazard rates among the groups.

  • d NA, not applicable.