TABLE 3

Univariate and multivariate analysis of the clinical factors predictive of complete virologic suppression during rescue therapy

VariableUnivariate analysisMultivariate analysis
Hazard ratioaP valuebAdjusted hazard ratioP value
Age (per yr)1.003 (0.978–1.028)0.843
Baseline serum HBV DNA (per 1 log10 IU/ml)0.584 (0.489–0.697)<0.0010.565 (0.461–0.692)<0.001
Baseline serum ALT (per IU/liter)0.998 (0.994–1.002)0.262
HBeAg (positive vs negative)0.700 (0.431–1.137)0.150
Liver cirrhosis (positive vs negative)c1.082 (0.655–1.787)0.760
Time point of rescue therapy
    Virologic breakthrough (yes vs no)0.747 (0.459–1.215)0.240
    Biochemical breakthrough (yes vs no)0.512 (0.298–0.879)0.0151.238 (0.664–2.309)0.501
Drug resistance0.078
    LAM/ETV-R vs LAM/ADV-R0.541 (0.316–0.924)0.024
    LAM/ETV-R vs LAM/ETV/ADV-R0.751 (0.414–1.362)0.345
    LAM/ADV-R vs LAM/ETV/ADV-R1.393 (0.751–2.584)0.294
  • a Data in parentheses are 95% CIs.

  • b P values were determined using Cox proportional hazards regression models. A P value of <0.05 indicates a significant difference.

  • c Liver cirrhosis was diagnosed when the platelet count was below 100,000/mm3 and associated splenomegaly or esophageal-gastric varices were detected.