Parameter^{a} | Population estimate | Bootstrap estimate^{b} | Precision (RSE)^{d} | |
---|---|---|---|---|

Base model | Final model | |||

Structural model | ||||

CL/F (liters/h) | 50.8 | 30.2 | 30.6 | 9.9 |

V/F (liters) | 2,090 | 1,100 | 1,110 | 12.8 |

k (h_{a}^{−1}) | 1.33 | 1.26 | 1.29 | 28.4 |

Absorption lag time (h) | 1.79 | 1.79 | 1.81 | 9.2 |

IIV and IOV | ||||

IIV CL/F (% CV) | 58.1 | 46.4 | 45.8 | 9.17 |

IIV V/F (% CV) | 73.8 | 30.2 | 29.6 | 32.3 |

IIV k (% CV)_{a} | 46.8 | 53.4 | 57 | 33.4 |

IOV F (% CV) | 28.6 | 23.6 | 23.7 | 13.4 |

F, volunteers vs patients^{c} | 257% | 123% | 126% | 26.5 |

Residual variability | ||||

Proportional error, study 1 (% CV) | 6.97 | 6.76 | 6.77 | 4.37 |

Proportional error, study 2 (% CV) | 62.7 | 53.8 | 52.8 | 8.34 |

↵a

*k*, first-order absorption rate constant; CL/F, apparent clearance;_{a}*V*/F, apparent volume of distribution; F, bioavailability.↵b Data obtained from nonparametric bootstrap analysis (200 data sets).

↵c Difference in bioavailability in healthy volunteers versus patients.

↵d RSE, relative standard error, expressed as a percentage.