TABLE 3

Significant covariate effects included in the final model

CovariateEffect on structural parameteraBootstrap estimate of effectPrecision (RSE)b
Effect on relative F
    Concurrent proton pump inhibitor−45.1−43.811.7
    Concurrent metoclopramide−34.5−33.521.3
    Concurrent nutritional supplement12912116.6
    Mucositis−57.7−57.75.61
    Diarrhea−45.1−38.615.5
Effect on CL/F
    Concurrent phenytoin/rifampin62164025.8
    Concurrent fosamprenavir34.234.323.4
  • a The percent increase or decrease (positive and negative values, respectively); data are the result of a nonparametric bootstrap analysis (200 data sets).

  • b RSE, relative standard error, expressed as a percentage.