TABLE 1

In vitro interactions by FIC indices of ISA in combination with MFG or AMB against different mold isolatesa

Isolate (strain)FIC index (median [range])
ISA-MFGISA-AMB
Aspergillus fumigatus (4215)0.75 (0.51–1.06)1.5 (0.53–2.5)
Aspergillus flavus (10B)0.59 (0.51–1.007)1.5 (0.14–2.25)
Aspergillus terreus (95644)0.625 (0.31–1.015)1.18 (0.14–2.12)
Fusarium oxysporum species complex (34)1.015 (0.507–1.5)1.37 (1.004–2.5)
Fusarium solani species complex (26)1.06 (1.007–1.5)1.06 (1–2.5)
Cunninghamella bertholletiae (182)0.59 (0.52–2)1.007 (0.5–2.12)
Lichtheimia corymbifera (187)0.75 (0.5–2.5)1.12 (0.56–2.5)
Mucor circinelloides (234)1.06 (1–1.5)1 (0.5–1.24)
Rhizopus microsporus (230)1.06 (1–1.5)1.03 (0.5–2.1)
Rhizopus oryzae (98)1.06 (1–1.5)1.09 (0.56–2.25)
Scedosporium apiospermum (142)0.28 (0.12–1)1.06 (0.5–1.25)
  • a FIC, fractional inhibitory concentration; ISA, isavuconazole; MFG, micafungin; AMB, amphotericin B deoxycholate.