TABLE 2

Residues in distal pocket having a higher contribution to substrate binding in AcrB than the corresponding residues in AdeB and AdeJa

Residue in AcrBResidue in:
AdeBAdeJ
F136FF
V139LV
Q176QQ
F178FF
G179GG
S180AG
I277FF
I278AD
Y327YY
F610TF
V612IV
F615WF
R620AV
F628FF
  • a Data for AcrB are from reference 16.