TABLE 2

Effects of tested compounds on the K. pneumoniae BAMC 07-18 biofilms

Group and compoundConcn used (μg/ml)aLog reduction of viable cell countsbChange(s) observed in BioFlux system
Antibiotics
    Imipenem≥12.54–5Biofilms were cleared
    Ciprofloxacin1002Some dead cells
    Rifampacin1003Many dead cells
    Tobramycin1004–5Lots of dead cells, biofilms were not cleared
Peptides
    KSL-W2001Some dead cells
    DJK-61004–5Lots of dead cells, biofilms were not cleared
    HHC10100No effectNo change
    HHC364001–2Not tested
    H53200No effectNot tested
Detergentsc
    CTAB0.1% (vol/vol)No effectNo change
    CPC0.07% (vol/vol)3–4Many dead cells
    SBMA1% (vol/vol)No effectNo change
    CAPB DC1% (vol/vol)No effectNo change
    Tristat P51% (vol/vol)3Lots of dead cells, biofilms were reduced but not cleared
    Delmonpinol2,000No effectNo change
    Dispersin B100No effectNo change
    cis-2-Decenoic acid500No effectNo change
Quorum-sensing inhibitors
    F-2195002Lots of dead cells
    F-217500No effectLots of dead cells
    F-195500No effectNo change
    Furanone C-3050No effectNo change
d-Amino acids
    d-Methionene5001No change
    d-Tryptophan500No effectNo change
    d-Leucine500No effectNo change
    d-Tyrosine500No effectNo change
  • a Concentrations used are in μg/ml unless otherwise noted.

  • b Based on MBEC assay.

  • c CTAB, hexadecyltrimethylammonium bromide; CPC, cetylpyridinium chloride; SBMA, sulfobetaine methacrylate.