TABLE 2

Summary of changes induced on daptomycin-susceptible and -nonsusceptible VRE by ampicillin or ceftaroline

CharacteristicResulta
DAP-susceptible VREDAP-nonsusceptible VRE
Synergy with DAP
    AMP+
    CPT++
Effect on cell wall thickness
    AMP↓↓
    CPT
Effect on membrane fluidity
    AMP
    CPT
Poly-l-lysine binding
    AMP
    CPT
Bodipy-DAP binding
    AMP
    CPT
LL37 binding and activity
    AMP
    CPT↑↑↑↑
  • a +, yes; −, no; ↓↓, more-marked decrease; ↓, decrease; ↑↑, more-marked increase; ↑, increase.