TABLE 1

Population pharmacokinetic parameters of cefquinome in rats after subcutaneous injection

ParameteraPopulation valueInterindividual variability (%)
Dose (mg/kg)10
Ka (1/h)5.53115
V/F (ml/kg)90049.6
CL/F (ml/h/kg)91226.8
AUC[0–∞] (μg × h/ml)10.9
T1/2elim (h)0.68
  • a Ka, absorption rate constant; V/F, apparent volume of distribution; CL/F, apparent plasma clearance; AUC, area under the plasma concentration curve; T1/2elim, terminal half-life.