TABLE 3

Efficacy of lychnopholide in mice experimentally infected with T. cruzi and treated with lychnopholide i.v. at 2.0 mg/kg/day using different schemes and formulations during the acute phase of the infection

Expt (strain)aExpt groupbParasitological cure (%)cSurvival (%)
I (CL strain)Controls00
LYC-PCL NC50100
Free LYC075
BZ (50 mg/kg, i.v.)100100
II (CL strain)Controls00
LYC-PCL NC100100
LYC-PLA-PEG NC100100
Free LYC050
BZ (50 mg/kg, i.v.)100100
III (Y strain)Controls00
LYC-PCL NC50100
Free LYC050
BZ (50 mg/kg, i.v.)0100
IV (Y strain)Controls00
LYC-PCL NC62.5100
LYC-PLA-PEG NC100100
BZ (50 mg/kg, i.v.)75100
  • a For more detail about the treatment schemes, see Table 1.

  • b Controls refers to untreated mice, unloaded NC, and control solution.

  • c Defined as a negative HC, PCR, or ELISA result.