TABLE 1

Antifungal activity of synthesized hydrazones against H. capsulatum var. capsulatum (n = 5) in yeast-like and filamentous forms

CompoundMolecular formulaMol wtMIC range (μg/ml) for:
Yeast formFilamentous form
N′-[1-Phenylethylidene]isonicotinohydrazideC14H13N3O239.37.8–25015.6–250
N′-[1-(2-Methoxyphenyl)ethylidene]isonicotinohydrazideC15H15N3O2269.362.5–1251,000–2,000
N′-[1-(3-Methoxyphenyl)ethylidene]isonicotinohydrazideC15H15N3O2269.331.25–1252,000
N′-[1-(4-Chlorophenyl)ethylidene]isonicotinohydrazideC14H12ClN3O273.7125125–500
N′-[1-(2-Nitrophenyl)ethylidene]isonicotinohydrazideC14H12N4O3284.331.25–125250–500
N′-[1-m-Tolylethylidene]isonicotinohydrazideC15H15N3O253.362.5–250250–500
N′-[1-(4-Nitrophenyl)ethylidene]isonicotinohydrazideC14H12N4O3284.362.5–250250–500
N′-(1,2-Diphenylethylidene)-2-isonicotinohydrazideC20H17N3O315.462.5–2501,000–2,000
N′-[1-(4-Bromophenyl)ethylidene]isonicotinohydrazideC14H12BrN3O318.162.5–125125–500