TABLE 3

Synergistic in vitro activity of N′-(1-phenylethylidene)isonicotinohydrazide combined with AMB against H. capsulatum in yeast-like and filamentous forms (n = 24)

H. capsulatum strainMIC (μg/ml) for drugs when:FICI
IsolatedCombined
N′-(1-phenyl)aAMBN′-(1-phenyl)AMB
YFYFYFYFYF
03-02-0901251250.50.53.93.90.00780.00190.0460.035
03-03-03515.631.20.50.53.91.00.00780.00090.2650.034
03-03-054NTb125NT0.5NT3.9NT0.0019NT0.035
03-03-05562.5NT0.125NT7.8NT0.0156NT0.2496NT
03-06-05931.2NT0.125NT7.8NT0.0156NT0.3744NT
05-01-096NT62.5NT0.5NT46.8NT0.0019NT0.753
05-01-097NT62.5NT0.25NT46.8NT0.0019NT0.752
05-02-018NT31.2NT0.0312NT1.0NT0.0009NT0.063
05-02-02162.5NT1.0NT3.9NT0.0078NT0.0702NT
05-02-03462.531.20.50.53.91.00.00780.00090.0780.034
05-02-035NT31.2NT0.125NT1.0NT0.0009NT0.039
05-02-042NT31.2NT0.0312NT23.4NT0.0009NT0.782
05-02-05362.5NT0.5NT7.8NT0.0156NT0.156NT
05-02-07462.5NT0.5NT7.8NT0.0156NT0.156NT
05-02-08415.662.50.50.03121.9523.40.00390.00090.1320.406
05-02-085NT62.5NT0.5NT46.8NT0.0019NT0.753
05-02-086NT62.5NT0.5NT23.4NT0.0009NT0.376
05-02-08762.562.51.01.03.93.90.007810.00190.0700.064
05-02-0882501250.50.57.823.40.01560.00090.0620.189
05-02-091NT125NT1.0NT23.4NT0.0009NT0.188
05-03-040NT125NT0.5NT1.0NT0.0009NT0.009
05-04-01562.531.20.01561.03.93.90.780.00190.5630.126
05-04-028NT62.5NT0.5NT1.0NT0.0009NT0.017
05-05-01131.2NT0.5NT7.8NT0.0156NT0.2808NT
  • a Y, yeast-like; F, filamentous.

  • b NT, not tested.