TABLE 3

Topoisomerase activity inhibition assays

AgentIC50, μMMIC, μMa
E. coli gyrase supercoilingE. coli topoisomerase IV ATPaseE. coli ARC523 (W3110)E. colitolC ARC524 (W3110)
Ciprofloxacin0.360.06<0.005
NBTI 54630.020.0030.50.05
  • a MICs converted to μM.