TABLE 4

Pseudomonas aeruginosa resistance mutation rates for NBTI 5463a

Concn, μg/ml (× MIC)Resistance rate
1 (2)1.8 × 10−7
2 (4)5 × 10−8
4 (8)3 × 10−8
8 (16)1 × 10−8
16 (32)Below detection limit
  • a P. aeruginosa PAO1 was grown to 7 × 109 CFU/ml, and a total of 0.3 ml was spread on an LB plate with the indicated compound concentration. The MIC for this strain was 0.5 μg/ml. Colonies were counted at 48 h of incubation.