TABLE 6

In vivo efficacy in neutropenic mouse models of P. aeruginosa and E. coli following intraperitoneal dosing of NBTI 5463

PD magnitudeAUC/MIC ratioa
P. aeruginosa ARC545 (PAO1)E. coli ARC1710, thigh
ThighLung
Stasis1657
−1 log24911
−2 log322226
  • a Free-fraction corrected AUC/MIC required for the indicated magnitude of pharmacodynamic response relative to CFU/ml of the starting inoculum.