TABLE 1

Drug susceptibility profiles of clofazimine-resistant and wild type M. tuberculosis

Strainrv0678 sequence characteristic(s)MIC (μg/ml) of:
ClofazimineBedaquilineEconazoleMoxifloxacin
H37RvWTa0.3120.12550.031
H37RvCFZ-R1c189a (S63R)1.250.5100.031
H37RvCFZ-R2c400t (R134stop)1.250.5100.031
H37Rv::pMV261WT0.3120.12550.031
H37Rv::rv0678WT0.3120.12550.031
H37Rv::rv0678(S63R)WT and S63R0.6250.2550.031
  • a WT, wild type.