TABLE 2

Characteristics of pKpQIL-like plasmid-harboring isolates and their E. coli DH10 transformants

IsolateaSpeciesSTbMIC (μg/ml)c
IPMERTMEMDORCTXCAZCFPATMTIC/CLASXTGENAMKTOBCIPLVXDOXTGCCSTPMB
13001K. pneumoniae258>8>4>8≥4>32>16≥32>16>128/2>4/76232≥16≥4>840.50.51
15720K. pneumoniae258>8>4>8≥4>32>16≥32>16>128/2>4/76>1632≥16≥4>8≤2≤0.250.51
26633K. pneumoniae2348>4>8≥4884>16>128/2≤0.5/9.5≤1≤4≤1≤0.25≤14≤0.250.51
28611K. pneumoniae258>8>4>8≥4>32>16≥32>16>128/2>4/762≥64≥16≥4>840.50.51
30799K. pneumoniae258>8>4>8≥4>32>16≥32>16>128/2>4/764≤4≥16≥4>880.50.51
28944E. aerogenes>8>4>8≥4>32>16≥32>16>128/2≤0.5/9.5≤1≤4≤1≤0.25≤1810.51
28960E. coli1318>4>8≥4>3216≥32>16>128/2>4/76≤1≤42≥4>8>160.511
13001TE. coli448≥4>32>16≥32>16>128/2≤0.5/9.5≤1≤4≤1≤0.25≤1≤2≤0.250.51
15720TE. coli8>48≥4>32>16≥32>16>128/2≤0.5/9.52≤4≤1≤0.25≤1≤2≤0.250.51
26633TE. coli4222884>16>128/2≤0.5/9.5≤1≤4≤1≤0.25≤1≤2≤0.25≤0.25≤0.25
28611TE. coli8>48≥4>32>16≥32>16>128/2≤0.5/9.5≤1≤4≤1≤0.25≤1≤2≤0.250.51
30799TE. coli424216168>16>128/2≤0.5/9.5≤1≤4≤1≤0.25≤1≤2≤0.250.5≤0.25
28944TE. coli8>48≥4>32>16≥32>16>128/2≤0.5/9.5≤1≤4≤1≤0.25≤1≤2≤0.250.51
28960TE. coli4122>32>1616>16>128/2≤0.5/9.5≤1≤4≤1≤0.25≤1≤2≤0.250.51
  • a T, E. coli DH10B transformant.

  • b —, not tested.

  • c MIC values were determined using broth microdilution; resistance values are indicated in boldface. IPM, imipenem; MEM, meropenem; ERT, ertapenem; DOR, doripenem; CAZ, ceftazidime; CTX, cefotaxime; CFP, cefepime; ATM, aztreonam; TIC/CLA, ticarcillin/clavulanate; AMK, amikacin; GEN, gentamicin; TOB, tobramycin; DOX, doxycycline; CIP, ciprofloxacin; LVX, levofloxacin; SXT, trimethoprim-sulfamethoxazole; TGC, tigecycline; CST, colistin; PMB, polymyxin B.