TABLE 3

Patients with non-IgE-mediated HSRs to nafcillin switched to cefazolina

Patient no.Age (yr)/genderInfectious diagnosisPathogenHSRDuration of therapy prior to HSR onset (days)Level of care required for HSR managementTherapy outcome
140/FProsthetic joint infectionMSSAMaculopapular rash9HospitalizationCompleted cefazolin
225/MEpidural abscessMSSAMaculopapular rash22HospitalizationCompleted cefazolin
350/MEpidural abscessMSSAMaculopapular rash26Office visitCompleted cefazolin
450/FSeptic arthritisGroup A streptococcusMaculopapular rash8HospitalizationCompleted cefazolin
580/FHardware infectionMSSAMaculopapular rash13Office visitCompleted cefazolin
641/MSeptic arthritisMSSAMaculopapular rash24HospitalizationCompleted cefazolin
769/FEndocarditisCoNSMaculopapular rash9Office visitCompleted cefazolin
864/FOsteomyelitisMSSAMaculopapular rash21Office visitCompleted cefazolin
926/MOsteomyelitisMSSAMaculopapular rash9HospitalizationCompleted vancomycin
1025/MOsteomyelitisCoNSMaculopapular rash7ED visitCompleted cefazolin
1172/MEndocarditisMSSAImmune-mediated nephritis19HospitalizationCompleted cefazolin
1248/FSeptic thrombophlebitisMSSAImmune-mediated nephritis13HospitalizationCompleted cefazolin
1373/MHardware infectionMSSAImmune-mediated nephritis15ED visitCompleted cefazolin
1454/MBacteremiaMSSAEosinophilia20HospitalizationCompleted cefazolin
1582/FOsteomyelitisMSSAEosinophilia36Office visitCompleted cefazolin
1679/FHardware infectionMSSASerum sickness19SNF visitCompleted cefazolin
1774/FOsteomyelitisMSSAImmune-mediated hepatitis20HospitalizationCompleted cefazolin
  • a Data are for 17 patients. Abbreviations: M, male; F, female; MSSA, methicillin-sensitive Staphylococcus aureus; CoNS, coagulase-negative Staphylococcus; ED, emergency department; SNF, skilled nursing facility.