TABLE 3

Most frequently identified mutations within 12 drug-resistance-associated loci among drug-resistant M. tuberculosis isolates

Drug (no. of drug-resistant isolates)LocusMutated positionNo. (%) of isolatesRelative frequency (%)a
INH (61)katG3154167.2
inhA−1569.8
RIF (46)rpoB5312247.8
5261021.7
51648.7
SM (35)rpsL432571.4
rrs(388–1084)514411.5
EMB (17)embB3061270.6
PZA (26)pncA96311.5
CAP (4)rrs(1158–1674)1401375.0
tlyANoneNAbNA
KAN (3)rrs(1158–1674)14013100.0
eisNoneNANA
AKM (2)rrs(1158–1674)14012100.0
eisNoneNANA
OFX (18)gyrA941055.6
90422.2
  • a Relative-frequency data represent comparisons to the total number of isolates resistant to the drug of interest.

  • b NA, not applicable.